Revia (Naltrexone)

Antagonist opioids. The highest affinity is for the μ- and κ-opioid receptors. Reduces the effect of opioid analgesics (analgesic, antidiarrhoeal, antitussive) eliminates the adverse effects of opioids (including endogenous), except for the symptoms caused by histamine reaction.

Inward. Treatment can be started after abstinence from drugs for 7-10 days (identified by urinalysis). The patient should not have the syndrome of "lifting" and signs of withdrawal. Treatment does not begin to until provocation testing with naloxone did not become negative.

In comparison with naloxone acts more strongly and for a long time. Can cause miosis (mechanism unknown). Combination with opioids in high doses leads to an increase in histamine release with a typical clinical picture (face flushing, itching, rash). In patients with opioid dependence is an abstinence attack. If alcoholism is associated with opioid receptors and blocks the effects of endorphins. Reduces the need for alcohol and prevents relapse within 6 months after the 12-week course of therapy (success of treatment depends on the consent of the patient). Long-term appointment does not cause tolerance and dependence. Onset of action - 1-2 hours.

If you miss a dose of the pills, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Store away from heat, moisture, and light. Store pills at 77 degrees F. Storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store in dampness plasess. Keep pills out of the reach of children and away from pets.

Hypersensitivity (including to naloxone), the state against the withdrawal of opioid dependence, acute hepatitis, hepatic failure, a positive test with naloxone. Whith carefull: Liver dysfunction and / or renal disease, pregnancy, lactation, age 18 years.

Part of the digestive system: more often - nausea and / or vomiting, abdominal pain, rarely - decreased or increased appetite, anorexia, diarrhea or constipation, dry mouth, flatulence, worsening symptoms of hemorrhoids, erosive and ulcerative lesions of the gastrointestinal tract, pain abdominal pain, increased activity of "liver" enzymes. The nervous system and sense organs: more frequently - anxiety, nervousness, unusual tiredness, weakness, restless sleep, "nightmarish" dream, headache, rare - dizziness, blurred vision, confusion, hallucinations, depression of the central nervous system, ringing and the feeling of fullness in the ears, pain and burning sensation in the eyes, photophobia, irritability, drowsiness, disorientation in time and space. The respiratory system: seldom - cough, hoarseness, nasal congestion (congestion of vessels nasal cavity), rhinorrhea, sneezing, bronchial obstruction, difficulty breathing, shortness of breath, epistaxis, dry throat, increased separation of the mucous phlegm, sinusitis. Cardio-vascular system: seldom - chest pain, high blood pressure, tachycardia, palpitations, nonspecific ECG changes, phlebitis. Genitourinary: discomfort when urinating, frequent urination, edema syndrome (swelling of face, fingers, feet, legs), sexual dysfunction in men (delayed ejaculation, decreased potency). Allergic reaction: less often - skin rash, flushing of the skin (including congestion s), rarely - pyrexia, pruritus, rarely - increased secretion of the sebaceous glands, chills. Other: more often - arthralgia, myalgia, rarely - thirst, increase or weight loss, pain in the groin, acne, alopecia, lymphadenopathy, lymphocytosis, and in one case, described the development of idiopathic thrombocytopenic purpura against pre-sensitized to the drug. Syndrome "abolition" of opioids: abdominal pain, cramping, epigastric, anxiety, nervousness, fatigue, irritability, diarrhea, tachycardia, hyperthermia, rhinorrhea, sneezing, "goose bumps", sweating, yawning, arthralgia, myalgia, anorexia, nausea and / or vomiting, tremors, weakness.

Revia is to be used only by the patient for whom it is prescribed. Do not share it with other people.